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研究表明,3号染色体短臂(the short arm of 3 chromosom e,3p)等位基因缺失在恶性肿瘤中频繁出现,提示3p区域可能存在对肿瘤发生发展起重要作用的抑癌基因。Damm ann等[1]利用酵母双杂交筛选方法首次在3p21.3内120 kb长的最小纯合缺失区克隆出1种能与DNA修复蛋白XPA相互作用的
Studies have shown that the deletion of allele of the short arm of 3 chromosom e (3p) on chromosome 3 is frequently found in malignant tumors, suggesting that there may exist tumor suppressor genes that play an important role in tumorigenesis in 3p region. Damm ann et al [1] using yeast two-hybrid screening method for the first time in 3p21.3 120 kb length of the minimal homozygous deletion region cloned a can interact with the DNA repair protein XPA