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目的观察小儿重症病毒性脑炎应用益生菌配合鼠神经生长因子的治疗方式的临床效果。方法选取湖北医药学院附属东风医院本院治疗的重症病毒性脑炎的170例患儿,采用随机数字表法的方式将患者随机分为观察组和对照组各85例,观察组在常规治疗的同时辅助益生菌及鼠神经生长因子,对照组仅辅助应用鼠神经生长因子进行治疗,对比两组患者的临床有效率;腹泻、惊厥、肢体肌力、意识等方面改善情况以及经过治疗后患儿的意识障碍程度,采用麦卡锡幼儿智能量表(MSCA量表)检查。结果观察组患儿的临床有效率显著高于对照组(94.12%vs 90.59%,P<0.05);两组患儿的惊厥消失时间差异无统计学意义[(2.02±0.94)d vs(2.94±0.96)d,P=0.059];观察组患儿的重症腹泻发生率显著低于对照组(5.88%vs 34.12%,P<0.01);观察组患儿肢体肌力恢复时间[(5.42±4.79)d vs(8.74±3.96)d]、意识恢复时间[(5.31±3.21)h vs(7.82±2.87)h]、锥体束征消失时间[(3.16±2.41)周vs(6.97±2.03)周]均低于对照组患儿(P均<0.01);观察组患儿治疗前后MSCA量表评分比较明显升高[(82.25±3.16)vs(102.25±5.41),P<0.05];观察组与对照组治疗前比较MSCA量表评分差异无统计学意义[(82.25±3.16)vs(83.34±2.98),P>0.05];观察组患儿治疗后MSCA量表评分显著高于对照组[(102.25±5.41)vs(94.28±6.47),P<0.05]。结论选择鼠神经生长因子的同时配合应用益生菌可以有效提高小儿重症病毒性脑炎的疗效,降低重症腹泻发生率,减少患儿肢体肌力恢复、意识恢复、锥体束征消失所用时间,提高患儿预后的智力状态,在一定程度上减少后遗症发生。
Objective To observe the clinical effect of using probiotics combined with nerve growth factor (NGF) in children with severe viral encephalitis. Methods 170 cases of severe viral encephalitis treated by our hospital affiliated to Dongfeng Hospital of Hubei Medical College were randomly divided into observation group and control group using random number table method. The observation group was treated with routine treatment At the same time, probiotics and mouse nerve growth factor were supplemented, and the control group only assisted with the application of rat nerve growth factor for treatment. The clinical efficacy of the two groups were compared; diarrhea, convulsion, limb muscle strength, awareness and other aspects of improvement and after treatment Of the degree of disturbance of consciousness, the use of McCarthy Toddler Intelligence Scale (MSCA scale) examination. Results The clinical effective rate in observation group was significantly higher than that in control group (94.12% vs 90.59%, P <0.05). There was no significant difference in the disappearance time of convulsion in both groups [(2.02 ± 0.94) d vs (2.94 ± 0.46) d, P = 0.059]. The incidence of severe diarrhea in the observation group was significantly lower than that in the control group (5.88% vs 34.12%, P <0.01) (vs (8.74 ± 3.96) d], recovery time [(5.31 ± 3.21) h vs (7.82 ± 2.87 h)], and disappearance time of pyramidal tract sign [(3.16 ± 2.41) vs (P <0.01). The scores of MSCA in observation group before and after treatment were significantly higher than those in control group [(82.25 ± 3.16) vs (102.25 ± 5.41), P <0.05] There was no significant difference in scores of MSCA between the two groups before treatment (82.25 ± 3.16 vs 83.34 ± 2.98, P> 0.05). MSCA score in the observation group was significantly higher than that in the control group [(102.25 ± 5.41) vs (94.28 ± 6.47), P <0.05]. Conclusion The application of probiotics combined with probiotics can effectively improve the therapeutic effect of severe viral encephalitis in children, reduce the incidence of severe diarrhea, reduce the recovery of muscle strength, recovery of consciousness, and the time spent in the disappearance of pyramidal tract signs The prognosis of children with intellectual status, to some extent, reduce the occurrence of sequelae.