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1989～1991年用胺碘酮硫酸镁联合治疗难治性心律失常37例,结果如下:一般资料 37例曾用多种抗心律失常药物未获明显疗效。原发病:冠心病18例,风心病9例,心肌炎6例,陈旧性心肌梗塞3例,先心病1例。持续性房颤12例,频发室性早搏9例,多源性早搏8例,偶发室性早搏8例。病程:2～24月。方法及疗效①25％硫酸镁液12～24ml,加入半量～全量极化液中静点,10～15天后停用硫酸镁及极化液。②口服胺碘酮0.2一日3次,第四天起改为1日1次维持。个别患者给予综合治疗措施。显效(心律失常完全控制)30例(82.1％);有效(发作频率减少1/2以上)4例(10.8％)。无效(发作频率减少低于1/2)3例(8.1％)。总有效率91.9％。用药见效最短时间20小时,平均70小时。讨论 (1)镁是体内重要的阳离子,主要存在
In 1989 to 1991 with amiodarone magnesium sulfate treatment of refractory arrhythmia in 37 cases, the results are as follows: General information 37 cases had a variety of anti-arrhythmic drugs without significant effect. Primary disease: 18 cases of coronary heart disease, rheumatic heart disease in 9 cases, myocarditis in 6 cases, 3 cases of old myocardial infarction, congenital heart disease in 1 case. 12 cases of persistent atrial fibrillation, frequent premature ventricular contractions in 9 cases, 8 cases of multi-source premature beats, 8 cases of premature ventricular premature beats. Course of disease: 2 to 24 months. Methods and efficacy ①25% magnesium sulfate solution 12 ~ 24ml, add half amount ~ full amount of polarization solution static point, 10 ~ 15 days after the withdrawal of magnesium sulfate and polarization solution. ② oral amiodarone 0.2 three times a day, from the fourth day on the 1st to maintain a change. Individual patients given comprehensive treatment. The curative effect (complete control of arrhythmia) was 30 (82.1%), and the effective rate (frequency of attack was reduced by 1/2) was 4 (10.8%). 3 cases (8.1%) were invalid (seizure frequency decreased by less than 1/2). The total effective rate of 91.9%. Medication effective minimum time 20 hours, an average of 70 hours. Discussion (1) Magnesium is an important cation in the body, mainly exists