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目的：测定布洛芬糖浆剂的药动学及相对生物利用度。方法：８名健康男性志愿者单剂量随机交叉ｐｏ４００ｍｇ布洛芬后，采用ＨＰＬＣ测定血浆药物浓度。结果：口服糖浆剂及片剂后血药浓度达峰时间分别为（０．８６±０．３０）ｈ和（１．７８±０．３４）ｈ，峰浓度分别为（４８．９±９．７１）μｇ·ｍｌ－１和（４４．２±８．２３）μｇ·ｍｌ－１，药时曲线下面积分别为（１７５．１±３１．９）μｇ·ｈ·ｍｌ－１和（１７８．６±２３．２）μｇ·ｈ·ｍｌ－１。结论：统计分析表明，糖浆剂较片剂达峰时间短，吸收快。布洛芬糖浆剂相对生物利用度为（９８．３±１４．５）％。
Objective: To determine the pharmacokinetics and relative bioavailability of ibuprofen syrup. Methods: Eight healthy male volunteers were randomized to a single dose of po400mg ibuprofen for determination of plasma drug concentration by HPLC. Results: The peak plasma concentrations of oral syrup and tablets were (0.86 ± 0.30) h and (1.78 ± 0.34) h, respectively, with peak concentrations of (48.9 ± 9) 71.1 μg · ml -1 and (44.2 ± 8.23) μg · ml -1, respectively, and the areas under the drug-time curve were (175.1 ± 31.9) μg · h · ml -1 and (178 .6 ± 23.2) μg · h · ml-1. Conclusion: Statistical analysis shows that the syrup has a faster absorption than the peak time of the tablet. The relative bioavailability of ibuprofen syrup was (98.3 ± 14.5)%.