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目的探讨血清胆固醇(TC、LDL-C)联合超敏C反应蛋白(hs-CRP)对幕上脑出血早期血肿扩大的预测价值。方法纳入发病在6小时内的103例急性幕上脑出血患者,分别于入院时以及发病24小时对患者行头颅CT扫描,同时在入院时行血清hs-CRP和TC、LDL-C水平检测,依据有无早期血肿扩大将患者分为实验组(血肿明显扩大)和对照组(血肿变化不大),对两组患者的血清hs-CRP和TC、LDL-C水平进行比较分析。结果实验组42例患者血清hs-CRP水平为(50.82±24.91)mg/L,明显高于对照组(18.16±10.73)mg/L(P<0.01)。而实验组血清TC、LDL-C水平分别为(3.59±0.74)mmol/L、(2.04±0.52)mmol/L,明显低于对照组(TC为5.24±0.91 mmol/L,LDL-C为3.29±0.83 mmol/L),差异均具有统计学意义(P<0.01)。结论血清hs-CRP水平联合血清TC、LDL-C水平可以更好的预测自发性幕上脑出血早期血肿扩大,为脑出血患者早期干预提供依据。
Objective To investigate the predictive value of serum cholesterol (TC, LDL-C) combined with hs-CRP in the early expansion of hematoma in supratentorial cerebral hemorrhage. Methods A total of 103 patients with acute supratentorial intracerebral hemorrhage (ICH) within 6 hours after onset were enrolled in this study. The patients underwent CT scans at admission and at 24 hours after onset. Serum levels of hs-CRP, TC and LDL-C were detected at admission. According to the presence or absence of early hematoma expansion, the patients were divided into experimental group (obviously enlarged hematoma) and control group (small change of hematoma). The levels of serum hs-CRP, TC and LDL-C were compared between the two groups. Results The serum level of hs-CRP in the 42 patients in the experimental group was (50.82 ± 24.91) mg / L, which was significantly higher than that in the control group (18.16 ± 10.73) mg / L (P <0.01). The levels of TC and LDL-C in experimental group were (3.59 ± 0.74) mmol / L and (2.04 ± 0.52) mmol / L, respectively, which were significantly lower than those in control group (TC was 5.24 ± 0.91 mmol / L and LDL-C was 3.29 ± 0.83 mmol / L), the differences were statistically significant (P <0.01). Conclusions Serum hs-CRP levels combined with serum TC and LDL-C levels can better predict the early hematoma expansion of spontaneous supratentorial intracerebral hemorrhage and provide basis for early intervention in patients with cerebral hemorrhage.