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酶学家早就知道同样的反应可由不同的酶(通常在于活性位点不同)催化(如胰蛋白酶和枯草杆菌蛋白酶)。相反,单一结构成分,如所有Ig,也可作为多种抗原的识别平台。新近《Cell》和《Science》刊登了系列文章,指出至少有一个生长因子受体家族兼具这两个特点,综合3个实验室资料,证实至少存在两类肿瘤坏死因子受体(TNFr)。这两类受体分子很明显仅在被认为是
It has long been known to the enzymeologist that the same reaction can be catalyzed by different enzymes, usually at different active sites (eg trypsin and subtilisin). Conversely, a single structural component, such as all Ig, can also serve as a platform for identifying multiple antigens. Recently, a series of articles published in Cell and Science pointed out that at least one growth factor receptor family has both of these characteristics. Based on three laboratory data, at least two types of tumor necrosis factor receptor (TNFR) have been identified. Obviously these two types of receptor molecules are only considered to be