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复发性肝炎(BTH)定义为HBV感染采用拉米夫定单一疗法治疗过程中的ALT再燃。已有许多关于逆转录酶C区拉米夫定耐药变异的报道,但是在拉米夫定治疗期间,这些变异的出现与BTH并不存在必然联系。方法和结果:对4例BTH患者和1例非BTH患者在拉米夫定治疗前和治疗期间的整个HBV基因组序
Recurrent hepatitis (BTH) is defined as a rebound of ALT during treatment of HBV infection with monotherapy of lamivudine. There have been many reports of lamivudine resistance mutations in reverse transcriptase C region, but the presence of these mutations is not necessarily related to BTH during lamivudine treatment. METHODS AND RESULTS: The entire HBV genome sequence was pre-treated and during lamivudine treatment in 4 BTH patients and 1 non-BTH patient