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应用免疫组化染色对20例喉乳头状瘤、20例声带息肉进行p53蛋白、增殖细胞核抗原(PCNA)、人乳头状瘤病毒(HPV)感染及树突状细胞(S-100~+DC)浸润检测。结果显示:p53蛋白阳性检出率45％(9/20),PCNA为70％(14/20),HPV为40％(8/20),S-100~+DC浸润为90％(18/20);声带息肉以上分子表达均为阴性。结果提示:(1)p53蛋白、PCNA较高表达提示肿瘤部分细胞向恶性转化,具有恶变的潜在危险,与喉乳头状瘤易复发、易恶变的生物学行为一致,实属交界性肿瘤:(2)HPV感染和喉乳头状瘤发病有关,或许说明此种病毒涉及喉乳头状瘤的病因-发病学环节;(3)S-100~+DC浸润率高,反映其在细胞免疫活动中极为活跃。
Immunohistochemical staining was performed on 20 cases of laryngeal papilloma and 20 cases of vocal cord polyps for p53 protein, PCNA, HPV infection and dendritic cells (S-100 ~ + DC) Infiltration detection. The results showed that the positive rate of p53 protein was 45% (9/20), PCNA was 70% (14/20), HPV was 40% (8/20) and S-100 ~ + DC was 90% 20); vocal cord polyp molecules were negative. The results suggest that: (1) The high expression of p53 protein and PCNA suggest the malignant transformation of some tumor cells, which has the potential risk of malignant transformation. It is consistent with the biological behavior of laryngeal papillomatosis and easy malignant transformation. 2) HPV infection and the incidence of laryngeal papilloma, may explain the cause of this virus involved in laryngeal papilloma - pathogenesis; (3) S-100 ~ + DC infiltration rate, reflecting its cellular immune activity is extremely active.