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对488名接触CS2女工月经状况与生殖结局进行了流行病学分析。结果显示,高浓度(10.42~46.54mg/m3)、低浓度(1.70~9.99mg/m3)或累积接触剂量(∑mg·年/m3)>60的接触CS2女工月经异常发生率均显著高于对照组,且呈良好的剂量-反应关系。多元逐步回归分析和多因素非条件Logistic回归分析进一步显示,CS2接触剂量与婚烟状况(已婚)是女工月经状况的两个主影响因素。分析认为,现行我国CS2最高容许浓度(MAC)对接触女工性腺生殖毒性的保护水平应予重新评估
An epidemiological analysis of the menstrual status and reproductive outcome of 488 women exposed to CS2 was conducted. The results showed that women exposed to CS2 had abnormal menstruation at high concentrations (10.42-46.54mg / m3), low concentrations (1.70-9.99mg / m3) or cumulative exposure doses (Σmg · year / m3) The incidence was significantly higher than the control group, and showed a good dose-response relationship. Multivariate stepwise regression analysis and multivariate non-conditional Logistic regression analysis further showed that CS2 exposure dose and status of married women (married) were the two main influencing factors of women’s menstrual status. Analysis, the current maximum allowable concentration of CS2 (MAC) of female workers should be re-assessed the level of protection of gonadal toxicity