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研究目的 探讨超微量肝素对婴幼儿重症肺炎并充血性心力衰竭的治疗作用。 研究方法 重症肺炎并充血性心力衰竭患儿40例,男21例,女19例,年龄6个月至2岁,随机分为超微量肝素治疗组(20例)和对照组(20例)。在一般性治疗基础上,治疗组加用肝素,每小时腹壁皮下缓慢注射一次,每次每公斤体重1单位(1mg=125单位),疗程为1～3天。 治疗结果 超微量肝素治疗组和对照组症状、体征恢复正常的时间有显著差异。两组中烦躁、面色改变、心率、心音、呼吸困难、肝肿大、尿量、下肢浮肿、心脏增大等恢复正常的时间分别为4.20±1.28小时比5.50±1.28小时(P<0.001)、7.10±1.41比10.10±2.07小时(P<0.001)、 4.40±1.05比5.18±1.21小时(P<0.05)、2.08±0.57比2.86±0.72小时(P<0.001)、4.06±0.91比4.96±0.72小时(P<0.005)、10.10± 1.14比11.20± 2.02小时(P<0.05)、10.20±1.54比11.53±1.97小时(P<0.001)、10.13±1.31比11.45±1.74小时(P<0.01)、21.60±7.39比23.40±7.26小时(P<0.001)。 研究结论 超微量肝素治疗婴幼儿重症肺炎合并充血性心力衰竭有效。
Objective To investigate the therapeutic effect of ultramicro-heparin on infantile severe pneumonia and congestive heart failure. Methods Forty patients with severe pneumonia and congestive heart failure, including 21 males and 19 females, aged 6 months to 2 years, were randomly divided into two groups: supermicro heparin group (n = 20) and control group (n = 20). On the basis of general treatment, the treatment group plus heparin, abdominal wall per hour slowly injected subcutaneous once per kilogram of body weight 1 unit (1mg = 125 units) for 1 to 3 days. The results of treatment of ultra-low-dose heparin treatment group and the control group symptoms, signs of recovery time were significantly different. 4.20 ± 1.28 hours and 5.50 ± 1.28 hours (P <0.001) respectively in two groups, which were irritability, complexion, heart rate, heart sound, difficulty breathing, hepatomegaly, urine output, lower limb edema and heart enlargement. 7.10 ± 1.41 vs 10.10 ± 2.07 hours (P <0.001), 4.40 ± 1.05 vs 5.18 ± 1.21 hours (P <0.05), 2.08 ± 0.57 vs. 2.86 ± 0.72 hours (P <0.001), 4.06 ± 0.91 vs 4.96 ± 0.72 hours (P <0.005), 10.10 ± 1.14 vs 11.20 ± 2.02 hours (P <0.05), 10.20 ± 1.54 vs 11.53 ± 1.97 hours (P <0.001), 10.13 ± 1.31 vs 11.45 ± 1.74 hours (P <0.01), 21.60 ± 7.39 vs. 23.40 ± 7.26 hours (P <0.001). Conclusion of the study of ultra-low-dose heparin treatment of severe pneumonia in infants and children with congestive heart failure.