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目的 了解锰(Mn)对人体的神经系统的损害,探索行为毒理学在职业流行病学研究中的实际应用价值,为进一步做好劳动保护工作提供依据。方法 采用WAIS成人智力量表中的成套行为指标及WHO推荐的“神经行为核心测验组合(MCTB)”,系统地对从事Mn作业人员进行测试,并设立对照组。结果 神经系统症状分数接触组比对照组高(P<0.01);接触组和对照组语言总分和操作总分两组均有显著性差异(P<0. 05);WHO核心行为功能测验 7个分测验的标准分两组之间大部分有显著性差异(P<0. 05);核心行为与专业工龄之间存在明显的负相关(P<0. 05);尿Mn与语言总分之间也存在明显负相关 (P<0. 01)。结论 长期低浓度的Mn接触对人体神经系统有明显的损害。
Objective To understand the damage of manganese to human nervous system and to explore the practical value of behavioral toxicology in occupational epidemiology and to provide basis for further labor protection. Methods Based on the set of behavioral indicators in the WAIS Adult Intelligence Scale and the “Neurobehavioral Core Combinations Test (MCTB)” recommended by the WHO, we systematically tested Mn workers and set up a control group. Results The score of neurological symptoms in the contact group was higher than that in the control group (P <0.01). There was significant difference between the total score of the language group and the total score of the operation group (P <0.05); the WHO core behavioral functional test 7 There was a significant difference between the two groups (P <0.05). There was a significant negative correlation between core behavior and professional seniority (P <0.05). Urinary Mn and total language score There was also a significant negative correlation (P <0.01). Conclusion Long-term low-level exposure to Mn significantly damages the human nervous system.