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目的对纯中药芪莲汤颗粒剂(Qilian soup-granula)进行小鼠急性毒性试验,判断芪莲汤颗粒剂的毒性毒理反应。方法以最大浓度和最大容量小鼠灌胃给药,24h内给药4次,给药结束后再观察7d。记录小鼠的死亡、体重等体征并检测血液肝功能(ALT、AST、TB、DB),肾功能(BUN、Cr),心肌标志物(CK)等指标。结果动物无死亡,与空白对照组比较体重无减轻等变化,肝、肾、心功能主要指标未出现受损提示。结论芪莲汤颗粒剂无明显急性毒性反应。
OBJECTIVE To study the acute toxicity of Qilian soup-granula to determine the toxicity of Qilian Tang granule. Methods The mice were administered intragastrically at the maximum concentration and the maximum capacity, four times within 24 hours and 7 days after the administration. The death, weight and other signs of mice were recorded and blood liver function (ALT, AST, TB, DB), renal function (BUN, Cr) and myocardial markers (CK) were measured. Results The animals died without any loss of body weight compared with the blank control group. The main indexes of liver, kidney and heart function were not damaged. Conclusion Qilian Decoction no obvious acute toxicity.