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Goals: To study the association between tobacco exposure and post- operative clinical recurrence in Crohn’ s disease patients and quantify the time to clin ical relapse following surgical resection. Background: It is well accepted that cigarette smoking has a negative impact on postoperative course in Crohn’ s dis ease. However, the effect of smoking to hasten clinical recurrence has not been clearly delineated. Study: We reviewed medical records of patients undergoing su rgical resection for medication- refractory disease within a 5- year period. P atients were followed for a period of 250 weeks. Outcomes were compared between smokers and nonsmokers and stratified by gender. Results: Fifty- nine patients were studied. Sixty- nine percent of smokers versus 23% of nonsmokers had rec urrent symptoms (P = 0.02) by the end of the observation period. There was no di fference in the mean ages, gender, disease location, use of postoperative medica tions, or number of postoperative visits (P > 0.09). Smoking was associated wit h an increased risk of clinical recurrence [odds ratio 2.96 (95% confidence in terval, CI 1.5- 5.6)]. The time to clinical relapse for smokers was 130 weeks v ersus 234 weeks in nonsmokers (P< 0.001). Conclusion: Smoking is associated with clinical recurrence of Crohn’ s disease, and the time to clinical recurrence in smokers is shorter. Strategie s for smoking cessation are warranted.
Goals: To study the association between tobacco exposure and post- operative clinical recurrence in Crohn ’s disease patients and quantify the time to clin ICAL relapse following surgical resection. Background: It is well accepted that cigarette smoking has a negative impact on postoperative course in However, the effect of smoking to hasten clinical recurrence has not been clearly delineated. Study: We reviewed medical records of patients undergoing su rgical resection for medication- refractory disease within a 5-year period. P patients were followed Outcomes were compared between smokers and nonsmokers and stratified by gender. Results: Fifty-nine patients were studied. Sixty-nine percent of smokers versus 23% of nonsmokers had rec urrent symptoms (P = 0.02) by the there was no di fference in the mean ages, gender, disease location, use of postoperative medica tions, or number of postoperative visits (P> 0.09). Smoking was associated with increased risk of clinical recurrence [odds ratio 2.96 (95% confidence in terval, CI 1.5-5.6)]. The time to clinical relapse for smokers was 130 weeks v ersus 234 weeks in nonsmokers (P <0.001). Conclusion: Smoking is associated with clinical recurrence of Crohn ’s disease, and the time to clinical recurrence in smokers is shorter. Strategie s for smoking cessation are warranted.