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A new γ-alkylated-γ-butyrolactone, named melongenolide A(1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A(1),(+)-syringaresinol(2),(+)- lyoniresinol(3), 5,5′-dimethoxy lariciresinol(4),(+)-(7R,8R)-4-hydroxy-3,3′,5′-trimethoxy-8′,9′-dinor-8,4′-oxyneoligna-7, 9-diol-7′- aldehyde(5), kaempferol-3-O-(2′′,6′′-di-O-p-trans-coumaroyl)-β-glucoside(6), arjunolic acid(7), vanillic acid(8), scoparone(9), and β-sitosterol(10). Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.
A new γ-alkylated-γ-butyrolactone, named melongenolide A (1), along with nine known compounds were obtained from the roots of Solanum melongena, and their structures were identified as melongenolide A (1), (+) - syringaresinol (+) - lyoniresinol (3), 5,5’-dimethoxylariciresinol (4), (+) - (7R, 8R) -4-hydroxy-3,3 ’, 5’-trimethoxy-8’, 9 -dinor-8,4’-oxyneoligna-7, 9-diol-7’-aldehyde (5), kaempferol-3-O- Compounds 2, 6, and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced (6), arjunolic acid (7), vanillic acid (8), scoparone (9), and β-sitosterol RAW 264.7 macrophages, with IC50 values being 5.62 ± 0.86, 11.47 ± 0.98, and 27.75 ± 1.26 μmol·L-1, respectively.