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目的:探讨心力衰竭患者心肌肌钙蛋白I(cTnI)、高敏C反应蛋白(hs-CRP)、B型钠尿肽(BNP)的联合诊断及预后判定。方法:选择2013年1月-2016年1月舟山市普陀区人民医院接诊的100例心力衰竭患者,并选择同期在该院进行体检的健康人员50名。比较心力衰竭组和健康组、不同心功能分级心力衰竭患者、有无发生心脏事件心力衰竭患者血清cTnI、hs-CRP、BNP的水平,并比较联合检测和单项检测的结果。结果:心力衰竭组cTnI、hs-CRP、BNP水平均比健康对照组高(P<0.05);不同心功能心力衰竭患者cTnI、hs-CRP、BNP水平中,Ⅱ级<Ⅲ级<Ⅳ级,三组比较差异具有统计学意义(P<0.05);发生心脏事件的心力衰竭患者cTnI、hs-CRP、BNP水平比未发生心脏事件的患者要高(P<0.05);血清cTnI、hs-CRP、BNP联合检测比单独检测敏感度、特异度、准确度高(P<0.05)。结论:在心力衰竭患者中进行cTnI、hs-CRP、BNP的联合诊断具有重要意义,可作为诊断病情及判断预后的参考依据。
Objective: To investigate the combined diagnosis and prognosis of cardiac troponin I (cTnI), high-sensitivity C-reactive protein (hs-CRP) and B-type natriuretic peptide (BNP) in patients with heart failure. Methods: From January 2013 to January 2016, 100 cases of heart failure admitted to Putuo District People’s Hospital of Zhoushan City were selected and 50 healthy people were selected for physical examination at the same hospital. The levels of serum cTnI, hs-CRP and BNP in heart failure patients and heart failure patients with or without heart failure were compared between the heart failure group and the healthy group. The results of combined testing and single test were compared. Results: The levels of cTnI, hs-CRP and BNP in patients with heart failure were higher than those in healthy controls (P <0.05). Among patients with different heart failure, the levels of cTnI, hs- The levels of cTnI, hs-CRP and BNP in patients with heart failure who had cardiac events were significantly higher than those without cardiac events (P <0.05). Serum cTnI, hs-CRP The detection of BNP was higher than the sensitivity, specificity and accuracy (P <0.05). Conclusion: The combined diagnosis of cTnI, hs-CRP and BNP in patients with heart failure is of great significance and can be used as a reference for diagnosis of disease and prognosis.