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在动物实验中,有人发现烟碱能兴奋周围化学感受器,对上气道(如颏舌肌)的兴奋和刺激作用大于膈肌,有可能减轻气道阻塞。基于上述实验,作者在8例睡眠呼吸暂停综合征病人中观察了烟碱对上气道阻塞的作用。病人平均年龄45岁(15～71岁)。6例超过标准体重30%;3例未经正规治疗;5例口服茶碱类药物;1例同时应用抗高血压药物和胰岛素。2例在清醒状态下有高碳酸血症(PaCO_2>60mmHg)。胸部X光片均正常。均无咳嗽和咳痰。实验记录从晚8时开始,用多导示波器分别监测脑电图、眼球运动、颏肌的肌电图和心电图。以感应体积描记仪监测呼吸。以热敏电阻器记录鼻道和口腔的气流。用耳氧计测氧饱和度。用红外CO_2分析仪由鼻塞取样测潮气末PCO_2。病人在口嚼含烟碱口香糖(总量14mg)后进行实验,以不服
In animal experiments, it was found that nicotine can excite the surrounding chemoreceptors, the excitement and stimulation of the upper airway (such as genioglossus muscle) than the diaphragm, it is possible to reduce airway obstruction. Based on the above experiment, the authors observed the effect of nicotine on upper airway obstruction in 8 patients with sleep apnea syndrome. The average age of patients 45 years (15 to 71 years old). Six patients were over 30% of standard body weight; three were not formally treated; five were theophylline orally; one was antihypertensive and insulin at the same time. Two patients had hypercapnia (PaCO 2> 60 mmHg) in conscious state. Chest X-ray films were normal. No cough and sputum. Experimental records starting from 8 pm, with multi-guided oscilloscope EEG, eye movement, electromyography and electrocardiogram of the chin muscle. Respiration was monitored with an induction plethysmograph. A thermistor is used to record nasal and oral airflow. Oxygen saturation with oxygen measurement. Infrared CO_2 analyzer was used to measure the end of the tidal volume of PCO_2 from the nasal obstruction. Patients chew with nicotine chewing gum (total 14mg) after the experiment to refuse