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目的 探讨实验性脊髓空洞症发病机制。方法 取中国白兔 2 4只 ,其中Kaolin组 (12只 )经皮枕大池穿刺注入Kaolin制作动物模型 ,生理盐水组和假手术组 (各 6只 )作对照。术后行Kaolin组MRI扫描并与光镜、电镜组织学对比。结果 2周时MRI发现上颈髓呈水肿、缺血性改变。 4～ 6周 ,90 %动物形成空洞。空洞随观察时间延长而逐渐增大、受累节段增多。组织学证实了MRI发现。结论 Kaolin性肉芽肿引起的上颈髓缺血 水肿和脑脊液循环障碍在脊髓空洞形成中发挥重要作用
Objective To investigate the pathogenesis of experimental syringomyelia. Methods Twenty-four Chinese rabbits were selected. The Kaolin group (12 rabbits) was injected into Kaolin percutaneous puncture into the animal model. The saline group and sham-operated group (6 rats each) were used as controls. After operation, the Kaolin group was scanned with MRI and histological comparison with light microscope and electron microscope. Results 2 weeks after MRI found that the upper cervical cord was edema, ischemic changes. 4 to 6 weeks, 90% of animals formed hollow. Void with the extension of observation time and gradually increased involvement of segments increased. Histologically confirmed MRI findings. Conclusion Kaolin granuloma caused by cervical spinal cord ischemia and edema and cerebrospinal fluid circulation disorders play an important role in the formation of syringomyelia