【摘 要】
：
目的探讨Alzheimer病(AD)患者认知功能和脑功能区的血流改变及其两者之间的关系.方法 40名AD患者、35名年龄和性别相对应的正常老年人均予认知功能及脑SPECT检查,并做相关性
【机 构】
：
上海医科大学附属华山医院老年科,上海,200040;上海市精神卫生中心
论文部分内容阅读
目的探讨Alzheimer病(AD)患者认知功能和脑功能区的血流改变及其两者之间的关系.方法 40名AD患者、35名年龄和性别相对应的正常老年人均予认知功能及脑SPECT检查,并做相关性研究.结果 AD患者的认知功能与同年龄组老年人相比有明显减低(P＜0.001),AD患者两侧大脑半球血流均有,但各功能区血流减低的程度不一样,其中以顶、颞、额叶、基底节血流降低的程度最为明显(P＜0.001),丘脑、枕叶血流降低程度与对照组相比也有统计学上的差异(P＜0.01,P＜0.05).相关性研究发现,AD患者语言和视觉空间障碍与左颞叶血流降低有关(P＜0.05),注意力和记忆力的障碍则与右额叶关系密切(P＜0.05).结论 AD患者存在认知功能障碍,其双侧大脑半球血流全面降低,且认知功能障碍与脑相关功能区低灌注密切相关.
其他文献
Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental en
Differentiation of human fibroblasts into functional neurons depends on the introduction of viral-mediated transcription factors, which present risks of viral g
会诊讨论会rn王向波主任医师:本例在出现手肌萎缩之前,一直按“脱髓鞘病”治疗,本次住会诊中心病房查肌电图(EMG)有巨大电位,显示以前角细胞损害为主,颈MRI(-),头MRI提示双侧
It is widely known that matal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of patal exercise have no
目的了解我国高龄老人生存现状及亟待解决的问题.方法采用描述性统计分析方法分城乡间、性别间进行讨论.结果高龄老人养老方式目前仍以家庭养老为最主要的形式,女性老人在反
A high glucose state readily causes peripheral axon atrophy, demyelination, loss of nerve fiber function, and delayed regeneration. However, few studies have ex
Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuro
Laser refractive surgery is one of the most performed surgical procedures in the world. Although regard-ed safe and efficient, it has side effects. All of the l
MicroRNAs (miRNAs) can regulate the modulation of the phenotype of Schwann cells. Numerous novel miRNAs have been discovered and identified in rat sciatic nerve