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目的:对广东省流动育龄妇女进行人乳头瘤病毒(HPV)筛查,为宫颈癌的预防提供依据。方法:应用SELDI-TOF-MS技术对人群进行HPV筛查,并检测16种HPV分型以及分析该群体的年龄、职业、教育程度和性生活史与感染率的关联性。结果:筛查26 766例人群中HPV感染率为6.77%。在各不同的分组中≥55岁组感染率最高(13.29%,P<0.05);商业/服务业组的感染率最高(5.72%,P<0.05);本科组的感染率最高(15.70%,P<0.05);性生活年限高于30年的感染率比其他组别都要高(11.90%,P<0.05);混合型别和单型别的感染也均是性生活年限在30年以上的感染率最高(2.84%和9.09%,P<0.05)。感染HPV型别主要为HPV16(1.39%)、HPV52(1.10%)、HPV58(0.83%)、HPV18(0.69%)。结论:广东省流动育龄妇女HPV感染率与全球总体趋势一致,HPV感染与人群年龄、职业、教育程度和性生活史密切相关,对人群进行HPV感染筛查能有效地防治宫颈癌,有良好的社会经济效益。
Objective: To screen human papillomavirus (HPV) for women of childbearing age in Guangdong Province to provide the basis for the prevention of cervical cancer. METHODS: HPV DNA screening was performed on the population using SELDI-TOF-MS technique. Sixteen HPV types were examined and their association with age, occupation, education, sex history and infection rate was analyzed. Results: HPV infection was 6.77% in 26,766 people screened. The highest infection rate was found in ≥ 55 years old group (13.29%, P <0.05) in different subgroups; the infection rate was the highest in commercial / service group (5.72%, P <0.05) P <0.05). The infection rate of sexual life more than 30 years was higher than that of other groups (11.90%, P <0.05). The mixed type and single type of infection were all more than 30 years The infection rate was the highest (2.84% and 9.09%, P <0.05). The main types of HPV infection were HPV16 (1.39%), HPV52 (1.10%), HPV58 (0.83%) and HPV18 (0.69%). Conclusion: The prevalence of HPV infection among women of childbearing age in Guangdong is consistent with the global trend. HPV infection is closely related to the age, occupation, education level and sexual life of the population. Screening for HPV in the population can effectively prevent and treat cervical cancer. Social and Economic Benefits.