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目的:通过对婴幼儿尿碘检测及神经行为发育水平的评估,探讨碘营养与神经行为发育的关系。方法:采用分层随机抽样的方法,收集2 329名婴幼儿,检测尿碘浓度,填写调查表,采用贝利婴幼儿发展量表评估神经行为发育情况。结果:①江苏省5地区婴幼儿尿碘中位数(MUI)为200μg/L,尿碘浓度(UIC)<100μg/L者为12.1%,UIC>300μg/L的为5.2%。②碘适宜组婴幼儿智能发育指数(MDI,105.91±15.574)高于碘缺乏组(103.22±18.144),F=-2.693,P=0.013;城市组婴幼儿MDI(106.62±15.879)明显高于农村组(101.62±14.265),t=7.656,P<0.001。③多元逐步回归分析显示,MDI与父母亲文化程度、尿碘水平可能有关,PDI与母亲文化程度、尿碘水平可能有关。结论:江苏省婴幼儿碘营养状况处于适宜水平;婴幼儿神经行为发育可能与其生活环境、父母文化程度尤其是母亲文化程度有关,碘缺乏可能对婴幼儿的神经行为发育产生不利影响。
Objective: To evaluate the relationship between iodine nutrition and neurobehavioral development by evaluating urinary iodine detection and neurobehavioral development in infants. Methods: A total of 2,229 infants and young children were collected by stratified random sampling. Urine iodine concentration was measured. The questionnaire was filled in and the behavior of neurobehavioral system was assessed by using the Bailey Infant Development Scale. Results: ① The urinary iodine median (MUI) was 200μg / L for infants and young children in 5 districts in Jiangsu Province, 12.1% for those with UIC <100μg / L and 5.2% for those with UIC> 300μg / L. (2) The index of MDI (105.91 ± 15.574) in iodine-appropriate group was higher than that of iodine deficiency group (103.22 ± 18.144), F = -2.693, P = 0.013; The MDI in urban group was significantly higher than that of rural Group (101.62 ± 14.265), t = 7.656, P <0.001. ③ Multiple stepwise regression analysis showed that MDI may be related to the level of parents’ education and urine iodine level. PDI may be related to mother’s education level and urine iodine level. Conclusion: The status of iodine nutrition in infants and young children in Jiangsu Province is at an appropriate level. The neurobehavioral development in infants and young children may be related to their living environment and parents’ educational level, especially their mother’s educational level. Iodine deficiency may adversely affect the neurobehavioral development of infants and young children.