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为了观察EHF灭活疫苗的免疫力和流行病学效果,选择一个发病率在380～860/10万的集体单位职工作为疫苗接种组,并以该单位所在地的同一景观生活的农民作为对照组(发病率在170～120/10万之间)。1989年10月首次免疫接种后,抗EHF病毒NT抗体阳转率为148/150,HI抗体为149/150;2种抗体的几何平均滴度分别为80.67和38.68。1年后抗体阴转为20～25%。1990年9月加强免疫接种后,NT抗体阳转率为100%,几何平均滴度为81.85,1年后阴转率为5～8%。经3年的流行病学效果观察,观察点再未发生EHF病例,认为该疫苗足以控制本病流行。
In order to observe the immunity and epidemiological effects of the EHF inactivated vaccine, a worker in a collective unit with an incidence rate of 380 to 860 / 100,000 was selected as the vaccination group and the peasants of the same landscape living in the same unit as the control group Incidence of 170 to 120 / 100,000). After the first immunization in October 1989, the anti-EHF virus NT antibody positive rate was 148/150 and HI antibody was 149/150; the geometric mean titers of the two antibodies were 80.67 and 38.68, respectively. 20 ~ 25%. After the intensified immunization in September 1990, the positive rate of NT antibody was 100%, the geometric mean titer was 81.85, and the negative conversion rate was 5-8% after one year. After three years of observation of epidemiological effects, the observation point and then no case of EHF, that the vaccine is sufficient to control the epidemic.