论文部分内容阅读
结核分支杆菌对各种抗菌素的耐药性,反映社区内所用化学治疗的质量,是国家结核病规程中用于流行病学监测的一个组成部分。耐药性的测定给生物学家提出了化验室方法的标准化和质量控制的问题。获得性和原发性耐药率的定义也要求将收集临床医生传递信息所用方法加以标准化。最后一点,计算得出的比率是否有效,取决于所选定对之进行了敏感试验的病人样本。因此,全国的耐药性调查需要多学科参加,以便挑选出仅有的有用指标,即原发性和获得性耐药率。这些经过长时期在有代表性的病人群体中收集来的指标,可用来衡量现代化学治疗方案对细菌的生态学造成的影响。
Mycobacterium tuberculosis resistance to various antibiotics reflects the quality of the chemotherapies used in the community and is an integral part of epidemiological surveillance in national tuberculosis protocols. The determination of drug resistance has given biologists the problem of standardization and quality control of laboratory methods. The definition of acquired and primary resistance also requires the standardization of methods used to collect information that clinicians transmit. Finally, whether the calculated ratio is valid depends on the sample of patients selected for the sensitivity test. Therefore, a nationwide drug resistance survey requires multidisciplinary participation in order to pick out the only useful indicators of primary and acquired resistance rates. These indicators, collected over a long period of time in a representative patient population, can be used to measure the impact of modern chemotherapies on bacterial ecology.