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喹诺酮类药物具有抗菌谱广、疗效显著,且相对于头孢菌素类、大环内酯类等药物价格低、药效高等优势,临床应用广泛。但随着近年来该类药物大量应用,其不良反应也在增多。根据国家药品不良反应监测中心2009年的统计,喹诺酮类药品不良反应报告数量仅次于头孢菌素类和青霉素类,居各类抗感染药第3位,占所有抗感染药严重不良反应报告的14.1%。现就喹诺酮类药物不良反应及临床合理应用情况综述如下。
Quinolones have broad antimicrobial spectrum and have significant curative effect. Compared with cephalosporins, macrolides and other drugs, quinolones have the advantages of low price and high efficacy, and are widely used clinically. However, with the large number of such drugs in recent years, the adverse reactions are also increasing. According to the statistics of the National Agency for Adverse Drug Reaction Monitoring in 2009, the number of quinolone adverse drug reactions reported was second only to that of cephalosporins and penicillins, ranking No. 3 in all kinds of anti-infectives, accounting for all the serious adverse reactions reported by anti-infectives 14.1%. Now on the quinolones adverse reactions and clinical applications are summarized below.