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目的 分析职业性急性二甲基甲酰胺 (DMF)中毒的临床特点及诊断要点。方法 收集 2 42例职业性急性DMF中毒病例临床资料 ,包括症状、体征、实验室检查及DMF代谢产物测定结果进行综合分析。结果 职业性急性DMF中毒的临床特点以消化系统损害为主要表现 ,其中腹痛较为突出 ,有时呈阵发性绞痛 ,常伴有SALT升高 ,本组12 0例腹痛者中有 85例SALT升高 ,占 70 5 % ,二者之间有很好的相关性。结论 诊断应基于明确的DMF接触史、现场调查、临床表现 ,特别是消化系统的表现以及尿中DMF及其代谢产物的测定结果。当然对DMF中毒的临床表现规律 ,应做进一步的研究。
Objective To analyze the clinical features and diagnosis points of occupational acute dimethylformamide (DMF) poisoning. Methods The clinical data of 2 42 cases of occupational acute DMF poisoning were collected, including the symptoms, signs, laboratory tests and the results of DMF metabolites determination. Results The clinical features of occupational acute DMF poisoning were mainly digestive system damage. Among them, the abdominal pain was prominent, sometimes with paroxysmal angina and often accompanied by an increase of SALT. Among the 120 cases of abdominal pain, 85 cases of SALT l High, accounting for 70 5%, there is a good correlation between the two. Conclusions The diagnosis should be based on a clear history of exposure to DMF, field investigations, clinical manifestations, in particular the performance of the digestive system, and the determination of DMF and its metabolites in the urine. Of course, the clinical manifestations of DMF poisoning should be further studied.