论文部分内容阅读
目的探讨儿童深部真菌感染情况,分析其对常用抗真菌药物的敏感性,为真菌感染的治疗和预防提供依据。方法回顾性分析了2009年3月~2012年12月延安大学附属医院270例确诊为深部真菌感染住院患儿的临床资料,药敏试验严格按照2006年CLSI M272A2规则及标准进行AmB、FCZ,5-FC、ICZ 4种抗真菌药敏检测。结果真菌感染样本主要来源于咽拭子,白假丝酵母的分离率最高61.11%,其次为光滑假丝酵母菌、热带假丝酵母菌、近平滑假丝酵母菌和克柔假丝酵母菌。药敏实验结果表明,假丝酵母菌对AmB、5-FC的敏感性较高。儿科患者中分离的真菌中以假丝酵母菌属最多,并以白假丝酵母菌为主。AmB、5-FC均有较高的抗真菌活性。结论应加强对临床真菌感染与耐药性情况的监测,以指导临床合理使用抗生素。
Objective To investigate the prevalence of deep fungal infection in children and to analyze its sensitivity to commonly used antifungal drugs and to provide evidence for the treatment and prevention of fungal infections. Methods The clinical data of 270 hospitalized patients with deep fungal infection in Yan’An Affiliated Hospital of Yan’an University from March 2009 to December 2012 were retrospectively analyzed. The drug susceptibility test was carried out in strict accordance with the rules and standards of CLSI M272A2 in 2006. AmB, FCZ, 5 -FC, ICZ four antifungal susceptibility testing. Results The fungal infection samples mainly came from throat swabs. The highest isolation rate of Candida albicans was 61.11%, followed by Candida glabrata, Candida tropicalis, Candida parapsilosis and Candida krusei. Susceptibility test results show that Candida sensitive to AmB, 5-FC higher. Among the fungi isolated from pediatric patients, Candida were the most common, and Candida albicans was the most common. AmB, 5-FC have higher antifungal activity. Conclusion The monitoring of clinical fungal infections and drug resistance should be strengthened to guide the rational use of antibiotics in clinic.