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目的分析降钙素原、新喋呤与乳酸对脓毒血症患者预后评估的临床价值。方法按预后将95例脓毒血症患者分成生存组和死亡组,其中生存组65例,死亡组30例,将发病早期的降钙素原、新喋呤与乳酸水平和ACHEⅡ评分进行对比,通过建立ROC曲线探讨标记物对于预后评估的临床意义。结果分析得知3种标记物水平和APACHEⅡ评分在2组患者中差异均具有统计学意义(P<0.05),并且3种标记物水平与APACHEⅡ评分具有明显的相关性;标记物阳性结果越多,病死率越高;3项标记物预测死亡的ROC曲线下面积在0.70~0.78之间。结论降钙素原、新喋呤与乳酸对脓毒血症患者的预后评估具有重要的临床研究价值,对患者的死亡具有较好的预测意义,并且联合检测能够提高预测的敏感程度。
Objective To analyze the prognostic value of procalcitonin, neopterin and lactic acid in patients with sepsis. Methods According to prognosis, 95 patients with sepsis were divided into survival group and death group, of which 65 patients in survival group and 30 patients in death group. The levels of procalcitonin, neopterin, lactate and ACHEⅡ were compared. The establishment of ROC curve to explore the clinical significance of markers for prognosis evaluation. Results The results showed that there was significant difference between the three markers and APACHEⅡscore in the two groups of patients (P <0.05), and there was a significant correlation between the three markers and APACHEⅡscore; the more the positive results of the markers , The higher the case fatality rate; the area under the ROC curve predicted by three markers was between 0.70 and 0.78. Conclusion The prognostic value of procalcitonin, neopterin and lactic acid in patients with sepsis has important clinical research value, which has a good predictive value for the death of patients, and combined detection can improve the sensitivity of the prediction.