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目的:探讨血清甲胎蛋白AFP,癌胚抗原CEA,糖类抗原CA 125、CA 19-9和CA 15-3对卵巢恶性肿瘤的联合诊断价值。方法:对182例卵巢良性肿瘤、137例卵巢恶性肿瘤和40名正常体检者血清AFP、CEA、CA 125、CA 15-3、CA 19-9水平同步测定并进行对照。结果:AFP、CEA、CA 125、CA 15-3和CA 19-9对卵巢恶性肿瘤诊断的灵敏度依次为13.87%,19.71%,81.02%,13.14%和42.34%,5项联合检测对卵巢恶性肿瘤诊断的灵敏度可提高为91.97%。结论:多种肿瘤标志物联合检测对卵巢恶性肿瘤诊断具有重要价值。
Objective: To investigate the diagnostic value of serum alpha-fetoprotein AFP, carcinoembryonic antigen CEA, carbohydrate antigens CA 125, CA 19-9 and CA 15-3 in ovarian cancer. Methods: The serum levels of AFP, CEA, CA 125, CA 15-3 and CA 19-9 in 182 cases of ovarian benign tumor, 137 cases of ovarian cancer and 40 normal subjects were measured simultaneously and compared. Results: The sensitivity of AFP, CEA, CA 125, CA 15-3 and CA 19-9 in the diagnosis of ovarian cancer were 13.87%, 19.71%, 81.02%, 13.14% and 42.34%, respectively. The diagnostic sensitivity can be increased to 91.97%. Conclusion: The combined detection of multiple tumor markers is of great value in the diagnosis of ovarian cancer.