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目的筛选遍地金提取物的抗抑郁活性组分,并初步了解各活性组分的抗抑郁作用机制。方法将遍地金提取物分为3个不同的组分,应用6种抗抑郁药理模型筛选抗抑郁活性组分。结果提取物中所有组分的中、小剂量均可显著增加大鼠成功逃避次数,大剂量均可显著减少小鼠的游泳不动时间;水、正丁醇提取组分各个剂量均可显著减少小鼠的悬尾不动时间。但5-HTP致小鼠甩头行为实验中,各组分无显著性差异;利血平及阿朴吗啡引起的体温降低试验中,各组分也无显著性差异。结论遍地金的水、正丁醇提取组分均有较好的抗抑郁作用,水提取组分的效果最佳,正丁醇提取组分次之。
Objective To screen the antidepressant components of the extract of Allium japonicum, and to understand the antidepressant mechanisms of the active components. Methods The extract of Allium mongolicum was divided into three different components and six antidepressant pharmacological models were used to screen antidepressant components. Results The middle and small doses of all the components of the extract could significantly increase the number of successful escape in rats, and the large dose of the extract can significantly reduce the immobility time of the mice; the dosage of water and n-butanol extract components can be significantly reduced Mouse tail time. However, there was no significant difference in the head-shaving behavior of mice induced by 5-HTP. There was no significant difference in the body temperature between reserpine and apomorphine. Conclusion The water and n-butanol extracts from all over the world have good antidepressant effect, and the water extractable components are the best, followed by n-butanol extract.