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单核巨噬细胞系统(MPS)在吞噬免疫复合物(IC)及组织碎屑时,同时释放溶酶体酶及炎症介质而损伤组织,故有清除IC及组织损伤的双重作用。两者为辩证统一的关系。近来,MPS对肾小球疾病的免疫病理作用已得到充分肯定。同时,许多学者也研究了MPS在肾小球疾病中清除IC的作用。这两方面的研究对探讨发病机理及临床治疗均有一定意义。本文将其研究近况作一综述。
Monocyte-macrophage system (MPS) in the immune phagocytosis of immune complexes (IC) and tissue debris, while releasing the lysosomal enzymes and inflammatory mediators damage the tissue, it has the dual role of clearing IC and tissue damage. The two are dialectically unified relations. Recently, the immunopathological effects of MPS on glomerular diseases have been fully affirmed. At the same time, many scholars have also studied the role of MPS in the clearance of IC in glomerular diseases. These two aspects of the study on the pathogenesis and clinical treatment are of some significance. This article reviews the current situation of its research.