论文部分内容阅读
目前临床上常用的肾小球滤过功能检查方法,如血尿素氮(Bun)血肌酐(Scr)、肌酐消除率(Ccr)等.对于判断原发或继发性肾小球疾病早期肾功能的改变都不够敏感.当肾小球滤过率(GFR)降低到正常的60%时,血(Bun)仍可正常;GFR至少降低1/3以上,Scr才会超出正常范围;GFR可随年龄增长而逐步下降.因此,为了尽早发现肾脏病患者,临床上肾功能检查正常,而实际已存在的功能损害,尽早给予适当处理,必须研究出更加灵敏的测定肾功能早期变化的方法.
Currently used in clinical glomerular filtration tests, such as blood urea nitrogen (Bun) serum creatinine (Scr), creatinine elimination rate (Ccr), etc. To determine the primary or secondary glomerular disease early renal function (GFR) is reduced to a normal level of 60%, the blood is still normal, GFR is reduced by at least a third or more, and Scr is out of the normal range Therefore, in order to detect renal disease patients as soon as possible, clinically normal renal function tests, and the actual functional impairment already exists, as soon as possible to give appropriate treatment, we must develop a more sensitive method for the determination of early changes in renal function.