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目的 探讨老年人肝癌DNA含量及其临床病理特点。方法 将865例肝癌患者分为老年组(199例)和对照组(666例),分析其临床特点,对56例切除标本行肝癌细胞DNA含量测定并对其他病理指标行比较性分析。其中老年组14例,对照组42例。结果 肝癌细胞DNA含量均为异倍体分布模式,老年人肝癌DNA含量及其他病理指标和对照组差异无显著性。临床上老年人肝癌具有病程长,就诊晚,临床表现不典型,多为右肝中晚期巨大肝癌的特点。老年人肝癌血清AFP阳性率低,γ-GT阳性率高,A/G比值倒置率高。结论 肝癌细胞DNA含量与年龄无关。老年人肝癌的DNA含量与对照组相似,但临床表现及其生化检查有其特殊性,故应加强对老年人肝癌的研究。
Objective To investigate the DNA content and its clinicopathological features of elderly patients with liver cancer. Methods 865 cases of liver cancer patients were divided into old group (199 cases) and control group (666 cases). Their clinical characteristics were analyzed. 56 cases of resection specimens were detected by DNA content of liver cancer cells and other pathological indicators were compared. There were 14 patients in the elderly group and 42 in the control group. Results The DNA content of hepatocellular carcinoma cells was an aneuploid distribution pattern. There was no significant difference in DNA content and other pathological parameters between the elderly and the control group. Clinically, the elderly with liver cancer has a long course of illness, a late presentation, and atypical clinical manifestations, mostly characterized by a large hepatocellular carcinoma in the middle and late stages of the right liver. The serum AFP positive rate of elderly patients with liver cancer is low, the positive rate of γ-GT is high, and the ratio of A/G ratio inversion is high. Conclusion The DNA content of hepatocellular carcinoma cells has nothing to do with age. The DNA content of elderly patients with liver cancer is similar to that of the control group, but the clinical manifestations and biochemical tests have their own particularities. Therefore, the study of elderly liver cancer should be strengthened.