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神经病变是糖尿病的常见并发症,多达50％～60％的糖尿病患者受累。糖尿病性神经病变呈进行性自然病程,不会自发缓解,目前也没有药物能逆转或停止其进程。本研究旨在了解下肢血管手术对于迟缓糖尿病神经病变进程的作用。 病人与方法 55例Ⅰ型或Ⅱ型糖尿病伴周围血管病变的病人参与本研究,均无肾功能不全、维生素B12缺乏、嗜酒、甲减或慢性呼吸功能不全。55例皆接受了下肢血管搭桥术。于手术前一天检查记录神经病变和肢体缺血程度;研究期间电话随访了解血管通畅情况,并于研究期末复查,共有21例的23条下肢接受了复查。失访的原因为路远和未能按时随访复查。但复查组患者与全组患者的性别、年龄、疾病程度相比无差异。55例平均年龄62岁(30～74岁),平均患糖尿病时间21年(1～57年)。神经病变的评估包括(1)根据“神经病变症状评分标准”评估首诊时足部与腿部神经病变症
Neuropathy is a common complication of diabetes, up to 50% to 60% of diabetic patients involved. Diabetic neuropathy is a progressive natural history, will not spontaneously alleviate, there is no drug to reverse or stop the process. The purpose of this study was to understand the role of lower extremity vascular surgery in retarding the progression of diabetic neuropathy. Patients and Methods 55 patients with type I or type II diabetes mellitus with peripheral vascular disease participated in this study. None of them had renal insufficiency, vitamin B12 deficiency, alcohol abuse, hypothyroidism, or chronic respiratory insufficiency. All 55 patients underwent lower limb bypass surgery. On the day prior to surgery, the degree of neuropathy and limb ischemia were recorded. During follow-up during the study period, patients were followed up for vascular patency and were reviewed at the end of the study period. Twenty-three of the 23 lower extremities were reviewed. The reasons for the loss of follow-up and failed to follow up on time follow-up review. However, there was no difference in the sex, age, and disease severity between the review group and the whole group. 55 patients with an average age of 62 years (30 to 74 years), the average duration of diabetes 21 years (1 to 57 years). Assessment of neuropathy includes (1) assessment of foot and leg neuropathy at first visit according to “Neurological Symptom Score Criteria”