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通过铑催化不对称催化氢化的方法,实现了2-苯基-2-丙烯醇的不对称催化氢化,对一系列单齿及双齿磷配体进行了筛选,在温和的条件下,以较高对映体选择性的合成了手性2-苯基丙醇,最高获得了70%的ee值。
Asymmetric catalytic hydrogenation of 2-phenyl-2-propenol was achieved by rhodium catalyzed asymmetric catalytic hydrogenation. A series of monodentate and bidentate phosphorus ligands were screened. Under mild conditions, Chiral 2-phenylpropanol was synthesized with high enantioselectivity, up to a 70% ee value.