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作者介绍了用重组α-2a干扰素（IFN-2-2a）治疗慢性丙型肝炎时,抗-IFN的检测情况。 对93例接受IFN-α-2a治疗的慢性丙型肝炎患者,在治疗期间及治疗后采集血清样本检测抗-IFN。A组先接受6百万单位（MU）IFN,每周3次,共4～6个月,然后减为3MU,每周3次,全疗程为1年;B组接受3MU IFN,每周3次,疗程亦为1年;C组接受6MU IFN,疗程为6个月。三个组的抗IFN中和抗体检出率分别为13％、22％和27％。提示不同给药方法可能影响抗-IFN的产生。各组抗-IFN
The authors describe the detection of anti-IFN in the treatment of chronic hepatitis C with recombinant interferon alpha-2a (IFN-2-2a). Of 93 patients with chronic hepatitis C treated with IFN-a-2a, serum samples were taken during and after treatment to detect anti-IFN. Group A first received 6 million units of (MU) IFN, 3 times a week for 4 to 6 months, then reduced to 3MU, 3 times a week, the whole course of treatment for 1 year; B group received 3MU IFN, 3 Times, the course of treatment is also 1 year; C group received 6MU IFN, treatment for 6 months. The detection rates of anti-IFN neutralizing antibodies in the three groups were 13%, 22% and 27%, respectively. Suggesting different administration methods may affect anti-IFN production. Groups of anti-IFNs