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目的:探讨HBeAg阴性CHB患者检测pre-S1Ag的意义。方法:收集我院感染科同时做pre-S1Ag、HBcAb-IgM及HBcDNA定量且HBsAg阳性的患者的资料160份,其中HBeAg阳性39例、HBeAg阴性121例,分析pre-S1Ag的表达与HBcAb-IgM及HBV DNA定量之间的关系。结果:HBeAg阴性CHB患者血清中pre-S1Ag检测阳性率明显低于HBeAg阳性CHB患者(P<0.05)。121例HBeAg阴性CHB患者血清中pre-S1Ag检测阳性率为35.5%,与HBc-IgM检测阳性率(38.8%)一致(P>0.05);pre-S1Ag阳性组HBV DNA检测率低于pre-S1Ag阴性组HBV DNA检测率,但两者之间的差别无统计学意义(P>0.05)。结论:pre-S1Ag可以作为反映HBV感染、复制的指标,但其在HBeAg阴性CHB患者中表达的意义待进一步研究。
Objective: To investigate the significance of detecting pre-S1Ag in HBeAg-negative CHB patients. Methods: The data of 160 patients with positive HBsAg, HBeAb-IgM and pre-S1Ag, HBcAb-IgM and HBcAg were collected simultaneously in our hospital. Among them, 39 were HBeAg-positive and 121 were negative for HBeAg. The expression of pre-S1Ag and HBcAb-IgM And HBV DNA quantitative relationship between. Results: The positive rate of pre-S1Ag in serum of HBeAg-negative CHB patients was significantly lower than that of HBeAg-positive CHB patients (P <0.05). The positive rate of pre-S1Ag in serum of 121 HBeAg-negative CHB patients was 35.5%, which was consistent with the positive rate of HBc-IgM (38.8%) (P> 0.05). The detection rate of HBV DNA in pre-S1Ag positive patients was lower than that of pre-S1Ag Negative HBV DNA detection rate, but the difference between the two was not statistically significant (P> 0.05). Conclusion: Pre-S1Ag can be used as an indicator of HBV infection and replication, but its significance in HBeAg-negative CHB patients needs further study.