安徽省农村地区风疹感染基线调查及风疹疫苗免疫效果观察

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对安徽省农村地区115名≤2岁~≥23岁的健康人检测了风疹血凝抑制(HI)抗体,结果表明:风疹HI抗体平均阳性率为67.89%;≤5岁儿童为43.85%;育龄期妇女易感率为8.59%。对361名≤2岁~≥23对岁的健康人接种了BRDⅡ株风疹减毒活疫苗,免疫应答研究结果表明:各年龄组对风疹疫苗均有较好的免疫应答反应;免疫前HI抗体阳性者接种风疹疫苗后仍可获得良好的免疫应答.说明我国选育的BRDⅡ株风疹减毒活疫苗具有良好的免疫原性。作者建议:①在全省建立风疹的监测系统;②将风疹疫苗的接种纳入计划免疫管理,实行1岁儿童完成初种及对婚前育龄期妇女给予1剂风疹疫苗的接种方案;③在条件许可的情况下,对全省农村地区14岁以下儿童进行普种. The results showed that the average positive rate of rubella HI antibody was 67.89% and that of children less than 5 years old was 43.85%. The HI antibody was detected in 115 healthy people ≤2 years old and ≥23 years old in rural areas of Anhui Province. The susceptibility of women of childbearing age was 8.59%. 361 healthy people aged ≤2 years and ≥23 years old were inoculated with live attenuated BRDⅡ strain of rubella vaccine. The results of immune response showed that all age groups had good immune response to rubella vaccine; the positive rate of HI antibody before immunization After vaccination rubella vaccine can still get a good immune response. This shows that BRDⅡ strain live attenuated vaccine in China has good immunogenicity. The authors suggest that: ① establish a rubella monitoring system in the province; ② vaccination of rubella vaccine into the planned immunization management, the implementation of a 1-year-old children to complete the first seed and prenuptial women of childbearing age given a rubella vaccination program; ③ conditions permit The case of children under the age of 14 in rural areas of the province.
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