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临床的日常经验指出许多有心功能不全症状的病例,应用洋地黄制剂得以成功地治疗,也能改善既患的心绞痛;但不伴随心功能不全的冠心病患者由于洋地黄的作用可使心绞痛症状恶化。临床诊断有负荷性冠血管功能不全,但无心功能不全的病人,在电刺激频率负荷实验中,较大治疗剂量的洋地黄化引起心肌缺血反应的增强,出现心绞痛发作,治疗剂量洋地黄引起心肌缺血性ST段下移的程度与剂量有关。然而无冠血管疾患的病人,洋地黄并不能使ST段明显下移。根据现在的看法,在洋地黄作用下,心肌对O_2的需要视心室肌的收缩状态
Clinical experience has shown that many cases of cardiac dysfunction symptoms, the use of digitalis preparations can be successfully treated, but also can improve the angina pectoris; but not with heart failure in patients with coronary heart disease due to digitalis can cause deterioration of angina symptoms . Clinical diagnosis of coronary heart disease with load insufficiency, but no heart failure patients in the frequency of electrical stimulation experiments, a larger dose of digitalis-induced myocardial ischemia increased, angina pectoris occurred, the treatment dose caused by digitalis The extent of myocardial ischemic ST segment down and dose. However, in patients without coronary artery disease, digitalis did not significantly lower the ST segment. According to the current view, under the action of digitalis, myocardial O 2 need depending on ventricular contraction state