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共选择３０例消化道肿瘤病人，其中食管癌、胃癌、大肠癌各１０例，设健康献血者３０例，对两组血清特异型组织多肽抗原（ｔｉｓｕｅｐｏｌｙｐｅｐｔｉｄｅｓｐｅｃｉｆｉｃａｎｔｉｇｅｎ，ＴＰＳ）浓度进行了检测，结果肿瘤组血清ＴＰＳ浓度明显高于健康人（Ｐ＜０．００１）。消化道肿瘤阳性检出率达７０％，其中食管癌８０％、胃癌６０％、大肠癌７０％。消化道肿瘤合并淋巴转移阳性检出率达７６．９％，其中食管癌１００％、胃癌６６．７％、大肠癌７０．０％。随着病程发展，血清ＴＰＳ浓度呈现升高趋势。本组３例４期肿瘤病人，血清ＴＰＳ浓度高达１０００Ｕ／Ｌ以上。结果提示，血清ＴＰＳ对消化道肿瘤阳性检出率较高，并与淋巴结转移及临床分期关系密切，血清ＴＰＳ水平越高，预后越差。
A total of 30 cases of gastrointestinal cancer patients were selected, including 10 cases of esophageal cancer, gastric cancer, and colorectal cancer. 30 healthy blood donors were included. The concentrations of serum-specific tissue polypeptide antigen (TPS) in two groups were examined. The concentration of serum TPS was significantly higher than that of healthy people (P<0.001). The positive rate of gastrointestinal cancers was 70%, including 80% of esophageal cancer, 60% of gastric cancer, and 70% of colorectal cancer. The positive rate of lymphatic metastasis in digestive tract tumors was 76.9%, including 100% for esophageal cancer, 66.7% for gastric cancer, and 70.0% for colorectal cancer. As the course of the disease progressed, serum TPS concentrations increased. In this group of 3 patients with stage 4 tumors, serum TPS concentrations as high as 1000U/L or more. The results suggest that the positive rate of serum TPS on digestive tract tumors is high, and it is closely related to lymph node metastasis and clinical stage. The higher the level of serum TPS, the worse the prognosis.