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目的：探讨Ｐ５３蛋白高表达在食管癌发病中的意义．方法：于１９９５年１０月～１２月在林县进行了病例对照调查，并收集了组织学材料．采用免疫组化ＳＰ法，对病例组（５９例）手术切除的癌组织和对照组（３７例）食管粘膜活检标本的Ｐ５３蛋白表达情况进行了检测．结果：５７．６％（３４／５９）的病例标本和１６．２％（６／３７）的对照标本存在有Ｐ５３蛋白高表达，病例组明显高于对照组（Ｐ＜０．０１）．单因素分析有显著意义的因素为Ｐ５３蛋白高表达、病前２０年食酸菜史、病前１０年食水果史和食管癌家族史，其比值比（ＯＲ）及其９５％可信限（ＣＩ）分别为７．０３（２．３３～２２．２１）、２．９８（１．１０～８．２０）、０．１９（０．０４～０．９０）和２．５１（０．９９～６．４４，Ｐ＜０．０５）．男性、女性Ｐ５３蛋白高表达的ＯＲ（９５％ＣＩ）及合并ＯＲ（９５％ＣＩ）分别为７．３８（１．９６～２９．６４）、８．１７（０．７７～２０３．３６）和７．５８（２．４１～２５．０１），与分层前ＯＲ接近．多因素Ｌｏｇｉｓｔｉｃ回归分析显示Ｐ５３蛋白高表达的ＯＲ（９５％ＣＩ）为５．９１（１．９５～１８．２７）．结论：结果提示Ｐ５３蛋白高表达与食管癌之间存在?
Objective: To explore the significance of high expression of P53 protein in the pathogenesis of esophageal cancer. Methods: A case-control survey was conducted in Lin County from October to December 1995. Histological materials were collected. The immunohistochemical SP method was used to detect the expression of P53 protein in the esophageal mucosal biopsy specimens of surgically resected cancer tissue and control group (37 cases) in the case group (59 cases). Results: There was a high expression of P53 protein in 57.6% (34/59) cases and 16.2% (6/37) of control specimens. The cases group was significantly higher than the control group (P<0.01). Factors with significant significance in univariate analysis were high expression of P53 protein, history of pickled cabbage for the first 20 years before illness, history of eating fruit before 10 years of illness, and family history of esophageal cancer. Their odds ratio (OR) and 95% confidence limit (CI) 7.03 (2.33 to 22.21), 2.98 (1.10 to 8.20), 0.19 (0.04 to 0.90), and 2.51 (0.99 to 6.44, P<0.05). The OR (95% CI) and combined OR (95% CI) of high expression of P53 protein in males and females were 7.38 (1.96 to 29.64) and 8.17 (0.77 to 203.36), respectively. 7.58 (2.41~25.01), close to OR before stratification. Multivariate Logistic regression analysis showed that the high expression of P53 protein in OR (95% CI) was 5.91 (1.95 to 18.27). Conclusion: The results suggest that there is a high expression of P53 protein and esophageal cancer?