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胰多肽(PP)曾被认为是胰岛素制品的一种杂质,但由于以下事实而被作为激素看待:1.其肽链羧基端氨基酸的酰胺化为肽类信使肽链所特有;2.PP与酪酪肽及酪神经多肽等生物活性肽类属于同一多肽族;3.在胰脏内分泌细胞分泌颗粒中存在着PP样免疫反应活性物质;4.PP在生理状况下大量释放入血;5.滴注PP使其血浓度上升至餐后水平,即可抑制已兴奋的胰腺外分泌和胆道运动。胰多肽的细胞来源与化学在各种动物包括人类,PP细胞都位于胰腺头部,该处PP细胞数量大于α细胞。最初分离的PP为三十六肽(PP 1～36),
Pancreatic polypeptide (PP), once considered an impurity of insulin preparations, is regarded as a hormone due to the fact that the amidation of the carboxyl-terminal amino acid of a peptide chain is peculiar to the peptide messenger peptide chain; Such as the casein peptide and bovine neural polypeptide belong to the same polypeptide family; 3 PP-like immunoreactive substances exist in the secretory granules of pancreatic endocrine cells; 4.PP release into the blood under physiological conditions; Instillation of PP to increase its blood concentration to the postprandial level, can inhibit the excitement of pancreatic exocrine and biliary motility. Cell Sources and Chemistry of Pancreatic Peptides In a variety of animals, including humans, PP cells are located in the head of the pancreas, where the number of PP cells is greater than the number of alpha cells. The first isolated PP was hexapeptide (PP 1 to 36),