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根据形态学特征,葡萄胎可分为完全性和部分性两类。从细胞遗传学角度,完全性葡萄胎是雄核发育的二倍体,大多数是纯合子,其基因起源可能是父亲染色体组中单倍体的复制。少数为杂合子,则由双精受精而来。部分性葡萄胎通常是三倍体,由一个母源和二个父源成分组成。近来,重组DNA技术的进展,数目可变的顺向重复(VNTR)标记物对确定妊娠物的基因起源特别有用。本研究中,使用2个以上VNTR标记物,包括APOB基因与人Ⅱ型胶原基因
According to morphological characteristics, hydatidiform mole can be divided into two types of complete and partial. From a cytogenetic point of view, complete hydatidiform mole is a diploid, mostly homozygous, and its gene origin may be haploid replication in the father’s genome. A small number of heterozygotes, from the double refined from. Partial mole is usually triploid, from a parent source and two parent components. Recently, advances in recombinant DNA technology and the number of variable tandem repeats (VNTR) markers are particularly useful for determining the gene origin of a pregnancy. In this study, two or more VNTR markers, including the APOB gene and human type II collagen gene