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目的 :检测阻塞性睡眠呼吸暂停综合征 (OSAS)合并慢性阻塞性肺病 (COPD)即重叠综合征(overlapsyndrome ,OS)患者血清中 β1-肾上腺素能受体与M2 -胆碱能受体自身抗体的变化。方法 :应用酶联免疫吸附法 (ELISA)检测OS患者 2 6例、OSAS患者 32例、COPD患者 30例及正常人 2 8例血清中抗 β1与M2 受体的自身抗体。结果 :β1与M2 受体的自身抗体阳性率及滴度 ,OS组 (92 2 % ,5 7 7%及 1∶98,1∶6 7)明显高于OSAS组 (71 9% ,40 6 %及 1∶83,1∶30 )和COPD组 (70 0 % ,36 7%及 1∶79,1∶2 8) (P <0 0 5 ) ,OSAS和COPD组显著高于正常对照组 (2 5 0 % ,14 3%及 1∶2 0 ,1∶2 0 ) (P <0 0 1)。结论 :OS ,OSAS与COPD患者血清 β1与M2 受体自身抗体明显高于正常人 ,且以OS患者为著
OBJECTIVE: To detect serum β1-adrenoceptor and M2-cholinergic receptor autoantibodies in patients with obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD), ie, patients with overlapsyndrome The change. Methods: Serum anti-β1 and M2 autoantibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 26 OS patients, 32 OSAS patients, 30 COPD patients and 28 normal controls. Results: The positive rate and titer of β1 and M2 receptor autoantibodies in OS group (92 2%, 57 7% and 1:98, 1:6 7) were significantly higher than those in OSAS group (71 9% and 40 6% And 1: 83,1: 30 respectively) and COPD group (70.0%, 36.7% and 1:79,1: 2 8) (P <0 05) .The OSAS and COPD groups were significantly higher than those in the normal control group 5 0%, 14 3% and 1: 2 0, 1: 2 0) (P <0 0 1). Conclusion: Serum β1 and M2 receptor autoantibodies in patients with OS, OSAS and COPD were significantly higher than those in normal subjects, and OS patients were