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为进一步了解颞颌关节（ＴＭＪ）对咬合创伤的反应及其机制，运用免疫组化法对所建立的咬合创伤动物模型ＴＭＪ软组织前列腺素Ｅ２（ＰＧＥ２）的分泌及变化进行观察。结果表明，咬合创伤ＴＭＪ软组织ＰＧＥ２分泌明显增多，其阳性反应最显著的是盘周肌肉，以翼外肌上头居首位，嚼肌次之。去除创伤后阳性反应明显减弱，但ＴＭＪ各部恢复程度不尽一致。提示ＴＭＪ软组织中对咬合创伤最敏感的是盘周肌肉，翼外肌上头损伤最重，其次是嚼肌；ＴＭＪ各部对咬合创伤反应的差异性影响损伤后的修复过程。
To further understand the TMJ response to occlusal trauma and its mechanism, immunohistochemistry was used to observe the secretion and changes of TMJ soft tissue prostaglandin E2 (PGE2) in an animal model of occlusal trauma. The results showed that the secretion of PGE2 in TMJ soft tissue of occlusal trauma was significantly increased. The most significant positive reaction was periampullary muscle, followed by the top of pterygoid muscle and the second of chewing muscle. The positive reaction was significantly weakened after the trauma was removed, but the degree of recovery of TMJ ministries was not consistent. It is suggested that the TMJ soft tissue is the most sensitive to the occlusal trauma. The periapical muscle is the most sensitive in the TMJ soft tissue. The top of the pterygoid muscle is the heaviest, followed by the chewing muscle. The differences between the TMJ departments in response to occlusal trauma and the post-injury repair process.