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为了解在乙型肝炎e抗体(抗-HBe)阳性的无症状携带者(ASC)和慢性活动性肝炎(CAH)病人之间,X基因突变是否与其乙型肝炎病毒(HBV)复制水平不同有关,作者对抗-HBe阳性的ASC和CAH病人血清HBV中的前核心区和X基因区进行了基因扩增和序列分析。病人和方法研究对象包括19例抗
To determine whether mutations in the X gene are associated with different levels of hepatitis B virus (HBV) replication between patients with hepatitis B e antigen (anti-HBe) -positive asymptomatic carriers (ASC) and chronic active hepatitis (CAH) , The authors performed gene amplification and sequence analysis of pre-core and X-gene regions in serum HBV against -HBe-positive ASC and CAH patients. Patients and Methods Subjects included 19 anti-patients