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目的了解血流感染多重耐药菌的分布及细菌耐药性,为有效控制病原菌传播及指导临床合理用药提供依据。方法对解放军251医院2012年1月—2014年12月住院患者血流感染的多重耐药病原菌进行统计及耐药性分析。结果该院住院患者血标本共检出多重耐药菌株150株,其中多重耐药革兰阳性菌58株,占38.7%,构成比较高的菌株为金黄色葡萄球菌。多重耐药革兰阴性菌93株,占62%,构成比较高的菌株为多重耐药大肠埃希菌。2013年耐药性最严重。结论该院血流感染多重耐药菌以肠杆菌科、葡萄球菌属和非发酵菌为主,所检出的多重耐药菌对临床普通抗菌药物的耐药性已比较严重,但对碳氢霉烯类、糖肽类、含有酶抑制剂抗菌药物敏感率仍较高,尚未发现血流感染全耐药菌。
Objective To understand the distribution and bacterial resistance of multi-drug resistant bacteria in bloodstream infection and provide the basis for effective control of the spread of pathogenic bacteria and clinical rational drug use. Methods Statistical analysis and drug resistance of multi-drug resistant pathogens in inpatients with bloodstream infection from 251 Hospital of PLA from January 2012 to December 2014 were analyzed. Results A total of 150 multidrug-resistant strains were detected in blood samples of hospitalized patients in this hospital, of which 58 were multi-drug resistant Gram-positive bacteria, accounting for 38.7%. Staphylococcus aureus was the most abundant strain. Ninety-three strains of multi-drug-resistant Gram-negative bacteria, accounting for 62%, were highly resistant strains of multi-drug resistant Escherichia coli. The most drug-resistant in 2013. Conclusion The multidrug-resistant strains of bloodstream infections in this hospital are Enterobacteriaceae, Staphylococcus and non-fermentative bacteria. The multidrug-resistant bacteria detected in the hospital are more resistant to common antibacterials. However, Mycotoxins, glycopeptides, enzyme inhibitors containing antimicrobial susceptibility is still high, no blood-resistant infections have been found fully resistant bacteria.