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目的观察小剂量环磷酰胺(CTX)冲击联合激素治疗狼疮性肾炎(LN)的疗效及其安全性。方法对治疗组18例行小剂量环磷酰胺联合激素治疗的狼疮性肾炎患者情况进行回顾性分析,并与对照组18例激素治疗患者进行比较。结果治疗9个月后,治疗组患者24 h尿蛋白定量、血肌酐、尿红细胞、血沉、狼疮活动积分较对照组组有明显好转,差异有统计学意义(P<0.05)。36例患者无一例出现不可逆或致死性不良反应。结论小剂量环磷酰胺冲击联合激素治疗狼疮性肾炎可显著增加疗效。
Objective To observe the efficacy and safety of low dose cyclophosphamide (CTX) combined with hormonal treatment of lupus nephritis (LN). Methods 18 cases of lupus nephritis treated with low dose cyclophosphamide combined with hormone therapy were retrospectively analyzed in the treatment group and compared with 18 cases of hormone therapy in the control group. Results After treatment for 9 months, 24 h urinary protein excretion, serum creatinine, urinary erythrocyte, erythrocyte sedimentation rate and lupus activity score in the treatment group were significantly improved compared with the control group (P <0.05). None of the 36 patients had an irreversible or fatal adverse reaction. Conclusion Low-dose cyclophosphamide combined with hormone treatment of lupus nephritis can significantly increase the efficacy.