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目的观察胃癌相关下调基因(GDDR)在胃癌及癌前病变中的表达变化,探讨GDDR在胃黏膜癌变过程中的作用和意义。方法应用免疫组化SP法测定经胃镜活检和病理确诊的40例正常胃黏膜组织,40例慢性浅表性胃炎,40例慢性萎缩性胃炎,40例胃的肠上皮化生,20例轻度异型增生,20例重度异型增生和40例胃癌中的GDDR蛋白表达情况。结果从正常胃黏膜组织、慢性浅表性胃炎、慢性萎缩性胃炎、胃肠上皮化生、轻度异型增生、重度异型增生、胃癌的发展过程中,GDDR蛋白表达逐渐下调(平均秩次分别为190.70、182.70、146.24、104.40、70.33、47.20和40.20),差异有统计学意义(P<0.05)。结论 GDDR表达下调发生在胃癌形成早期,提示GDDR在胃癌的早期诊断和治疗中起重要作用,有望成为胃癌早诊的分子标记物和分子治疗的新靶点。
Objective To observe the expression of GDDR in gastric cancer and precancerous lesions and to explore the role and significance of GDDR in the carcinogenesis of gastric mucosa. Methods 40 cases of normal gastric mucosa, 40 cases of chronic superficial gastritis, 40 cases of chronic atrophic gastritis and 40 cases of gastric intestinal metaplasia were detected by immunohistochemical SP method. Dysplasia, 20 cases of severe dysplasia and 40 cases of gastric cancer GDDR protein expression. Results GDDR protein expression was gradually down-regulated from normal gastric mucosa, chronic superficial gastritis, chronic atrophic gastritis, gastrointestinal metaplasia, mild dysplasia, severe dysplasia and gastric cancer (mean rank rank 190.70,182.70,146.24,104.40,70.33,47.20 and 40.20), the difference was statistically significant (P <0.05). Conclusions The down-regulation of GDDR occurs in the early stage of gastric cancer, suggesting that GDDR plays an important role in the early diagnosis and treatment of gastric cancer. It is expected to become a new target of molecular marker and molecular therapy for early diagnosis of gastric cancer.