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在原虫血症上升期，致死株约氏疟原虫（Ｐ，ｙ，）感染鼠脾细胞的增殖反应受到抑制，无γ－干扰素（ＩＦＮ－γ）产生，血清中未产生特异抗体，仅产生与正常鼠相同的白细胞介素２（ＩＬ－２０）；与此不同，非致死株Ｐ．ｙ．感染鼠脾细胞增殖反应增强，产生ＩＦＮ－γ及更多的ＩＬ－２，血清中还无特异抗体产生。在原虫血症下降期，脾细胞的增殖反应升高，较上升期有更多的ＩＬ－２及ＩＦＮ－γ生成，体内血清中出现滴度较高的特异抗体。免疫鼠脾细胞的增殖反应较前两者明显升高，体内血清特异抗体水平亦明显上升，ＩＬ－２及ＩＦＮ－γ水平与感染鼠原虫下降期相同。表明在Ｐ．ｙ．感染小鼠中，致死株的初次感染可抑制细胞免疫，非致死株在原虫上升期即可出现细胞免疫。原虫下降期细胞免疫功能进一步增强，高水平抗体生成在清除原虫中可能起重要作用
In the stage of protozoalmia, the proliferative response of murine spleen cells infected with lethal strain of Plasmodium yoelii (P, y,) was inhibited, and no IFN-γ was produced, no specific antibody was produced in serum and only the In contrast to normal mice, interleukin 2 (IL-20); in contrast, non-lethal P. y Infected mice spleen cell proliferation response to produce IFN-γ and more IL-2, serum no specific antibody. In the descending stage of parasitemia, the proliferative responses of splenocytes were increased, with more IL-2 and IFN-γ than those in the ascending stage, and high titers of specific antibodies appeared in the serum. The proliferative response of splenocytes in immunized mice was significantly higher than that in the former two, and the level of serum specific antibody was also significantly increased. The levels of IL-2 and IFN-γ were the same as those of infected mice. Show in P. y Infected mice, the initial infection of lethal strains can inhibit cellular immunity, non-lethal strains in the protozoal cellular immunity can occur. Protozoal cell immune function is further enhanced, high levels of antibody production may play an important role in the clearance of protozoa