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目的了解江苏省菌痢发病规律,分析菌型分布和药物敏感性特征,为菌痢防治提供科学依据。方法采用描述流行病学方法对2010-2012年江苏省菌痢监测资料进行分析,同时应用血清凝集和K-B纸片法进行血清分型和药物敏感性分析。结果2010-2012年江苏省菌痢年均发病率为8.49/10万,发病高峰是5-10月份,占3年总发病数的72.39%;在地区上呈散发态势,常州、镇江和徐州3市年均发病率最高;年龄分布以低年龄组为主,05岁组年均发病率最高。福氏志贺菌是优势菌群,其中F2a最多,占41.50%;宋内志贺菌变化显著。志贺菌对萘啶酸耐药率最高,其次为氨苄西林、四环素和复方新诺明。所有检测的抗生素中氨苄西林的耐药率增长最快。结论2010-2012年江苏省菌痢发病率较往年有所降低,志贺菌菌群比例变化显著,耐药及多重耐药现象日益严重。
Objective To understand the incidence of bacillary dysentery in Jiangsu Province, analyze the distribution of bacteria and the characteristics of drug sensitivity, and provide a scientific basis for the prevention and treatment of bacillary dysentery. Methods Descriptive epidemiological methods were used to analyze the surveillance data of bacillary dysentery in Jiangsu Province from 2010 to 2012. Serum typing and K-B method were used to detect the serotypes and drug susceptibility. Results The annual incidence rate of bacillary dysentery in Jiangsu Province was 8.49 / 100 000 between 2010 and 2012, and the peak incidence was from May to October, accounting for 72.39% of the total incidence in 3 years. In the region, Changzhou, Zhenjiang and Xuzhou 3 The average annual incidence of the city is the highest; the age distribution is dominated by the lower age group, and the highest annual incidence rate is in the 05-year-old group. Shigella flexneri is the dominant bacteria, which F2a up, accounting for 41.50%; Shigella sonnei significant changes. Shigella has the highest resistance rate to nalidixic acid, followed by ampicillin, tetracycline and cotrimoxazole. Ampicillin was the fastest-growing drug among all tested antibiotics. Conclusion The incidence of dysentery in Jiangsu Province decreased from 2010 to 2012 as compared with previous years. The proportion of Shigella bacteria changed significantly, and the resistance and multidrug resistance were becoming more and more serious.