Capsule ~(13)C-urea breath test for the diagnosis of Helicobacter pylori infection

• 作 者: Kwok-Hung Lai Ren-Shyan Liu Shui-Cheng Lee Daw-Guey Tsay Ching-Chu Lo Huei-Hwa Tseng Wen-Keui Huang Gin-Ho Lo Ping-I Hsu
• 机 构: Department of Nuclear Medicine,Department of Nuclear Medicine,Institute of Nuclear Energy Research,D
• 出 处: World Journal of Gastroenterology
• 发表日期: 2005年09期
• 关键词: breath histology capsule histological hundred stomach specificity biopsy modalit

AIM: To compare the accuracy of capsule 13C-urea breath test (UBT) with conventional invasive methods for the diagnosis of Helicobacter pylori infection. METHODS: One hundred patients received CLO test, histological examination, culture and 100- or 50-mg capsule UBT for the diagnosis of H pylori infection. H pylori infection was defined as those with positive culture or positive results from both histology and CLO test. RESULTS: Both the sensitivity and specificity of the 100-mg capsule UBT (n=50) were 100%. The sensitivity and specificity of the 50-mg capsule UBT (n = 50) were 96.4 and 100%, respectively. Taken together, the accuracy of capsule UBT (n =100) was higher than that of CLO test, histology and culture (100% vs 92%, 91% and 89%, respectively; P= 0.035, 0.018 and 0.005, respectively). Our data showed that the optimal timing of sampling for 100-and 50-mg capsule UBT was 15-30 and 6-15 min, respectively. CONCLUSION: Capsule UBT has a higher accuracy compared with biopsy-based tests. It is an ideal method for the diagnosis of H pylori infection.

AIM: To compare the accuracy of capsule 13C-urea breath test (UBT) with conventional invasive methods for the diagnosis of Helicobacter pylori infection. METHODS: One hundred patients received CLO test, histological examination, culture and 100- or 50-mg capsule UBT for the diagnosis of H pylori infection. H pylori infection was defined as those with positive culture or positive results from both histology and CLO test. RESULTS: Both the sensitivity and specificity of the 100-mg capsule UBT (n = 50) were 100% . The sensitivity and specificity of the 50-mg capsule UBT (n = 50) were 96.4 and 100%, respectively. Taken together, the accuracy of capsule UBT (n = 100) was higher than that of CLO test, histology and culture 100% vs 92%, 91% and 89% respectively; P = 0.035, 0.018 and 0.005, respectively). Our data showed that the optimal timing of sampling for 100- and 50-mg capsules UBT was 15-30 and 6- 15 min, respectively. CONCLUSION: Capsule UBT has a higher accuracy compared with biopsy-based t ests. It is an ideal method for the diagnosis of H pylori infection.